Top: Adult rat hippocampus immunohistochemistry. Bottom: Immunofluorescence staining of hippocampal CA3 of adult WT and Slo1 KO mice with L6/60 (red) and Kv2.1 rabbit polyclonal (green).

Top: Adult rat hippocampus immunohistochemistry. Bottom: Immunofluorescence staining of hippocampal CA3 of adult WT and Slo1 KO mice with L6/60 (red) and Kv2.1 rabbit polyclonal (green).

Epitope mapped to within amino acids 690-715 (PKLMRHDPLLIPGNDQIDNMDSNVKK, 100% conserved in mouse, rat, human, horse, dog, pig, cow, Rhesus monkey and rabbit, indicated by arrow in image at right) by Daniel Levy (University of Chicago).

Epitope mapped to within amino acids 690-715 (PKLMRHDPLLIPGNDQIDNMDSNVKK, 100% conserved in mouse, rat, human, horse, dog, pig, cow, Rhesus monkey and rabbit, indicated by arrow in image at right) by Daniel Levy (University of Chicago).

Immunoblot versus crude membranes from adult rat brain (RBM) and WT and Slo1 KO mouse brains probed with L6/60 TC supe.

Immunoblot versus crude membranes from adult rat brain (RBM) and WT and Slo1 KO mouse brains probed with L6/60 TC supe.

from NeuroMab

Slo1 maxi-K+ channel (7x-022)

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Volume: Purified: 100 µL; Purified Trial: 20 µL; TC Supernatant: 5 mL

Concentration: Purified: 1 mg/mL; TC Supernatant: Lot Specific

Clonality: Monoclonal

Form: Purified and TC Supernatant Available (select your preferred form, size and quantity before clicking "Add to Cart")

Host Species: Mouse

Immunogen: Fusion protein amino acids 690-1196 (cytoplasmic C-terminus) of mouse Slo1 (accession number AAA39746)
Human: 99% identityRat: 100% identity
Epitope mapped within amino acids 690-715 by Dr. D. Levy (Univ of Chicago); segment is 100% conserved in mouse, rat, human, horse, dog, pig, cow, Rhesus monkey, rabbit.

Target Description: mSlo maxi K+ channel (Calcium-activated potassium channel subunit alpha-1) is a member of BK channel alpha subunit family and has the particularity to be regulated by both Ca2+ and membrane depolarization.BK channels have a tetrameric structure. Each subunit is the product of the KCNMA1 gene. All modulatory subunits encoded by KCNMB1, KCNMB2, KCNMB3, or KCNMB4 can associate with the tetrameric channel. MSlo plays a major role in controlling cell excitability, which regulates smooth muscle contractions, transmitter release, and innate immune system cell activation. MSlo maxi-K+ channel contributes to repolarization of the membrane potential as it exports K+ out of the cytosol.

Gene ID: Kcnma1 Kcnma

Antibody Registry ID (RRID): AB_2249538

Physical State: Liquid

Validation and Application Notes

Molecular Weight: 110-130 kDa

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.


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