Volume: Purified: 100 µL; Purified Trial: 20 µL; TC Supernatant: 5 mL

Concentration: Purified: 1 mg/mL; TC Supernatant: Lot Specific

Clonality: Monoclonal

Form: Purified and TC Supernatant Available (select your preferred form, size and quantity before clicking "Add to Cart")

Host Species: Mouse

Immunogen: Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1(also known as N-methyl-D-aspartate receptor subunit NR1, NMDAR1, NMD-R1, GRIN1, Glutamate receptor subunit zeta-1 and Glurz1, accession number P35439)
Mouse: 99% identity (319/320 amino acids identical)
Human: 99% identity (317/320 amino acids identical)
<50% identity with other Glutamate receptors

Target Description: Glutamate receptor 1, NMDA 1, or GluN1/NR1 also known as subunit 1 of the N-methyl-D-aspartate (NMDA) receptor. It is a member of the glutamate receptor channel superfamily and is a heteromeric glutamate-gated calcium ion channel. GluN1 is essential for synaptic function in the brain. GluN1 is expressed throughout the brain in cerebellum, thalamus, olfactory bulb and cortex in the membrane at postsynaptic density. GluN1 plays a key role in synaptogenesis, synaptic plasticity, memory acquisition and learning. Mutations in the GluN1 gene are associated with intellectual disability and cortical visual impairment and movement disorders.

Gene ID: Grin1 Nmdar1

Antibody Registry ID (RRID): AB_11000180

Physical State: Liquid

Validation and Application Notes

Molecular Weight: 105 kDa

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.

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Citations

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