Excellent dopaminergic neuronal marker for use in IHC! We are the original manufacturer of our Tyrosine Hydroxylase sheep polyclonal antibody. It is affinity purified from pooled serum, and great in WB, IHC, and ICC.
Volume: 100 µL (Standard), 25 µL (Trial Size)
Concentration: Lot Specific
Form: Antigen Affinity Purified from Pooled Serum
Host Species: Sheep
Species Reactivity: Human, Mouse, Rabbit, Rat
Applications: WB, IHC
Immunogen: SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma
Target Description: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001).
Gene ID: TH
Antibody Registry ID (RRID): AB_2492277
Physical State: Liquid
Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Validation and Application Notes
Molecular Weight: 60
Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.