Immunostaining of rat brainstem showing specific labeling using our anti-ChAT antibody. Image courtesy of Dr. Robert Sloviter, University of Arizona.
Details
Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer's disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).
Volume: 100 µL
Concentration: Lot Specific
Clonality: Polyclonal
Form: Affinity Purified
Host Species: Goat
Species Reactivity: Avian, Chicken, Guinea Pig, Human, Mouse, non-Human primates
Applications: WB, IHC
Immunogen: Recombinant human choline acetyltransferase
Protein Name / Synonyms: 315
Gene ID: CHAT
Antibody Registry ID (RRID): AB_2492055
Physical State: Liquid
Conjugate: Unconjugated
Buffer: 100 µl in PBS + 5 mg/ml BSA + 0.2% NaN3
Validation and Application Notes
Molecular Weight: 70
Storage
-20 C
NOTE
Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.