Immunostaining of rat brainstem showing specific labeling using our anti-ChAT antibody. Image courtesy of Dr. Robert Sloviter, University of Arizona.

Immunostaining of rat brainstem showing specific labeling using our anti-ChAT antibody. Image courtesy of Dr. Robert Sloviter, University of Arizona.

Western blot of rat hippocampal lysate showing specific immunolabeling of the ~70 kDa ChAT.

Western blot of rat hippocampal lysate showing specific immunolabeling of the ~70 kDa ChAT.

Anti-ChAT (Choline Acetyltransferase) (315-CHAT)

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Product Details


Details

Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer's disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).

Volume: 100 µL

Concentration: Lot Specific

Clonality: Polyclonal

Form: Affinity Purified

Host Species: Goat

Species Reactivity: Avian, Chicken, Guinea Pig, Human, Mouse, non-Human primates

Applications: WB, IHC

Immunogen: Recombinant human choline acetyltransferase

Protein Name / Synonyms: 315

Gene ID: CHAT

Antibody Registry ID (RRID): AB_2492055

Physical State: Liquid

Conjugate: Unconjugated

Buffer: 100 µl in PBS + 5 mg/ml BSA + 0.2% NaN3

Validation and Application Notes

Molecular Weight: 70

Storage

-20 C

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.


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