Immunostaining of fibrotic mouse lung tissue showing specific staining of collagen I molecules (Cat. #621-COLP, 1:100, red) that are still associated with the cells in which they were synthesized. The blue is staining DNA.

Immunostaining of fibrotic mouse lung tissue showing specific staining of collagen I molecules (Cat. #621-COLP, 1:100, red) that are still associated with the cells in which they were synthesized. The blue is staining DNA.

Western blot of rat lung lysate showing specific immunolabeling of the ~180 kDa collagen 1.

Western blot of rat lung lysate showing specific immunolabeling of the ~180 kDa collagen 1.

Anti-Collagen 1, alpha 1 propeptide (321-COLP)

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Product Details


Details

Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the most abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the first 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005)

Volume: 100 µL

Concentration: Lot Specific

Clonality: Polyclonal

Form: Antigen Affinity Purified

Host Species: Rabbit

Species Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Immunogen: Synthetic peptide corresponding to amino acid residues specific to the collagen 1, alpha 1 propeptide conjugated to KLH

Gene ID: COL1A1

Antibody Registry ID (RRID): AB_2492060

Physical State: Liquid

Conjugate: Unconjugated

Buffer: 100 ul in PBS

Validation and Application Notes

Molecular Weight: 180

Storage

-20 C

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.


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