The FTO gene is the most robust gene for common obesity characterized to date. FTO gene expression has been found to be significantly upregulated in the hypothalamus of rats after food deprivation and strongly negatively correlated with the expression of orexin peptide which is involved in the stimulation of food intake (Fredricksson R et al., 2008). Deletion analysis of FTO gene in mice showed that FTO is functionally involved in the control of both energy intake and energy expenditure (Fischer J et al., 2009).
Volume: 100 µL
Concentration: Lot Specific
Form: Protein G purified culture supernatant
Host Species: Mouse
Antibody Isotype: IgG
Species Reactivity: Human, Mouse, Rat
Applications: WB, IF
Immunogen: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH
Gene ID: FTO
Antibody Registry ID (RRID): AB_2492098
Physical State: Liquid
Buffer: 100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Validation and Application Notes
Molecular Weight: 58
Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.