Western blot of rat testes lysate showing specific immunolabeling of the ~58 kDa FTO protein.

Western blot of rat testes lysate showing specific immunolabeling of the ~58 kDa FTO protein.

from PhosphoSolutions

Anti-FTO (Fat mass and obesity related protein) (597-FTO)

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Product Details


Details

Volume: 100 µL (Standard), 25 µL (Trial Size)

Concentration: Lot Specific

Clonality: Monoclonal

Form: Protein G purified culture supernatant

Host Species: Mouse

Antibody Isotype: IgG

Species Reactivity: Human, Mouse, Rat

Applications: WB, IF

Immunogen: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH

Target Description: The FTO gene is the most robust gene for common obesity characterized to date. FTO gene expression has been found to be significantly upregulated in the hypothalamus of rats after food deprivation and strongly negatively correlated with the expression of orexin peptide which is involved in the stimulation of food intake (Fredricksson R et al., 2008). Deletion analysis of FTO gene in mice showed that FTO is functionally involved in the control of both energy intake and energy expenditure (Fischer J et al., 2009).

Gene ID: FTO

Antibody Registry ID (RRID): AB_2492098

Physical State: Liquid

Conjugate: Unconjugated

Buffer: 100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Validation and Application Notes

Molecular Weight: 58

Storage

-20 C

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.


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