Anti-IBA1/AIF1 Antibody

Name: Anti-IBA1/AIF1 Antibody
Brand: Aves Labs
SKU: IBA1-0100
Price: 410.0 USD
Availability: InStock

from Aves Labs Datasheet

Our Anti-IBA1/AIF1 chicken primary antibody from AvesLabs is manufactured in-house. It detects IBA1/AIF1, and is purified. It is provided in liquid form.

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Western blot of rat brain membrane lysate using chicken α-AIF1/IBA1 showing specific immunolabeling of endogenous AIF1/IBA1 at ~17kDa.

Immunofluorescence of AIF1/IBA1-FLAG transfected COS-7 cells using chicken α-AIF1/IBA1 (green) and mouse α-flag tag (red). Yellow/orange staining shows 100% correspondence between the two antibodies for recognition of transfected cells. Blue staining is DAPI and stains nuclei of both transfected and untransfected cells.

Volume: 500 µL

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Product Details

Target

IBA1/AIF1

Target Description

AIF1, allograft inflammatory factor-1, (also known as Iba1, Ionized calcium binding adaptor molecule 1) is a 17 kDa protein that is a pro-inflammatory molecule that mediates calcium signals (Ito, D. et al 1998). During inflammation, increased expression of AIF1 occurs in microglia, macrophages, T-cells, synoviocytes, and adipocytes (Watano, K., et al, 2001). Expression of AIF-1 has been observed in healthy brains and varies throughout the day, gaining the highest expression in the prefrontal and parietal cortices when sleeping (Romcy-Pereira, R.N, et al, 2009). Increased expression of AIF1 has been observed in several diseases including breast cancer (Liu, S., et al 2008), atherosclerosis (Utans, U., et al, 1995), and rheumatoid arthritis (Kimura, M., et al, 2007).

Antigen

Purified recombinant human full-length IBA1/AIF1 (Uniprot P55008) expressed in E.Coli(Human)

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

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Ice packs

UniProt Details

UniProt (Human): P55008
UniProt (Immunogen Species): P55008

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Anti-IBA1/AIF1 Antibody

Our Anti-IBA1/AIF1 chicken primary antibody from AvesLabs is manufactured in-house. It detects IBA1/AIF1, and is purified. It is provided in liquid form.