Anti-Kv1.2 K+ Channel Antibody (K14/16)

Name: Anti-Kv1.2 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-008
Price: 335.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated Trial Size

filler

Clonality

Monoclonal

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

KCNA2

Molecular Weight

80 kDa

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Adult rat hippocampus immunohistochemistry.

Immunoblot on brain membranes from wild-type (WT) and Kv1.2 knockout (Kv1.2-/-) mice and from adult rat brain (RBM).

Immunoblot on membranes from whole rat (RBM) and mouse (MBM) brain and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

Variant

Price:

$335

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Product Details

Target

Kv1.2 K+ channel

Target Description

Kv1.2 K+ channel (Potassium voltage-gated channel subfamily A member 2), which is encoded by KCNA2 gene, is part of the Potassium voltage-gated channel family. Kv1.2 K+ channel switches between its open and closed conformation in response to the voltage difference across the membrane, which selectively allows the traffic of K+. Kv1.2 K+ channel determines potassium ion permeability of excitable membranes according to their electrochemical gradient. Therefore, this protein has for function to regulate neurotransmitter release, neuronal excitability, smooth muscle contraction, heart muscle contraction or insulin secretion. Kv1.2 is recognized as a tansmembrane/ multi-pass membrane protein. Anti-Kv1.2 K+ channel K14/16 is often used in IHC on human normal cerebral cortex.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K14/16

Isotype

IgG2b

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

KCNA2

Molecular Weight

80 kDa

Antigen

Fusion protein amino acids 428-499(cytoplasmic C-terminus) of rat Kv1.2 (accession number P63142), Epitope mapped to within amino acids 463-480; Human: 100% identity; Mouse: 100% identity

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2296313

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Conjugate

Unconjugated

Specificity

No cross-reactivity against Kv1.1, Kv1.3, Kv1.4, Kv1.5 and Kv1.6 expressed in transfected cells

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium voltage-gated channel subfamily A member 2 (NGK1) (Voltage-gated K(+) channel HuKIV) (Voltage-gated potassium channel HBK5) (Voltage-gated potassium channel subunit Kv1.2)

UniProt Details

UniProt (Human): P16389
UniProt (Immunogen Species): P16389

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Anti-Kv1.2 K+ Channel Antibody (K14/16)

Anti-Kv1.2 K+ Channel Antibody
SKU: 75-008

Product Details

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Anti-Kv1.2 K+ Channel Antibody (K14/16)

Anti-Kv1.2 K+ Channel Antibody SKU: 75-008

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Anti-Kv1.2 K+ Channel Antibody
SKU: 75-008