Anti-P-Zero Myelin Protein Antibody


Two antipeptide antibodies were generated in chickens against sequences shared between the mouse (NP_032649) and human (NP_000521) gene products. Antibodies were affinity-purified and mixed in equal concentrations. These antibodies have been validated with human, mouse and rat tissues.

Primary Antibody
Human, Mouse, pig, Rat
ICC, IHC, IP, WB
Chicken
Affinity-Purified IgY
MPZ
27 kDa

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Anti-P-Zero Myelin Protein Antibody
SKU: PZO

Volume: 1000 µL
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Sale price$440


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Product Specific References for Applications and Species

Immunocytochemistry: Human
PMID Dilution Publication
285126491:500Stratton, J.A., et al. 2017. Purification and Characterization of Schwann Cells from Adult Human Skin and Nerve. eNeuro, .
Immunocytochemistry: Mouse
PMID Dilution Publication
371276731:1000Govindappa, P.K., et al. 2023. A critical role for erythropoietin on vagus nerve Schwann cells in intestinal motility. BMC Biotechnology, 12.
352966511:1000Govindappa, P.K., et al. 2022. Erythropoietin promotes M2 macrophage phagocytosis of Schwann cells in peripheral nerve injury. Cell death & disease, 245.
342881201:500Booth, D.G., et al. 2021. Characterizing the molecular etiology of arthrogryposis multiplex congenita in patients with LGI4 mutations. Glia, 2605-2617.
299769261:500Volpi, V.G., et al. 2018. Zika Virus Replication in Dorsal Root Ganglia Explants from Interferon Receptor1 Knockout Mice Causes Myelin Degeneration. Scientific Reports, 10166.
297785231:250Park, J., et al. 2018. Local Immunomodulation with Anti-inflammatory Cytokine-Encoding Lentivirus Enhances Functional Recovery after Spinal Cord . Molecular Therapy, 1756-1770.
Immunocytochemistry: Rat
PMID Dilution Publication
362229461:1000Suzuki, T., et al. 2022. Molecular and Regenerative Characterization of Repair and Non-repair Schwann Cells. Cellular and Molecular Neurobiology, .
Immunohistochemistry: Human
PMID Dilution Publication
285126491:500Stratton, J.A., et al. 2017. Purification and Characterization of Schwann Cells from Adult Human Skin and Nerve. eNeuro, .
Immunohistochemistry: Mouse
PMID Dilution Publication
36479906not listedProcacci, N.M., et al. 2022. Kir4.1 is Specifically Expressed and Active in Non-myelinating Schwann Cells. Glia, .
363508841:300Shackleford, G., et al. 2022. A New Mouse Model Of Charcot-Marie-Tooth 2J Neuropathy Replicates Human Axonopathy And Suggest Alteration In Axo-Glia Communication. PLoS Genetics, e1010477.
363508841:300Shackleford, G., et al. 2022. A New Mouse Model Of Charcot-Marie-Tooth 2J Neuropathy Replicates Human Axonopathy And Suggest Alteration In Axo-Glia Communication. PLoS Genetics, e1010477.
36307805not listedManto, K.M., et al. 2022. Erythropoietin-PLGA-PEG as a Local Treatment to Promote Functional Recovery and Neurovascular Regeneration After Peripheral Nerve Injury. Journal of Nanobiotechnology, 461.
342407061:200Malavasi, E.L., et al. 2021. Dynamic early clusters of nodal proteins contribute to node of Ranvier assembly during myelination of peripheral neurons. eLife, e68089.
337283921:200Ehsanipour, A., et al. 2021. Injectable, macroporous scaffolds for delivery of therapeutic genes to the injured spinal cord. APL Bioengineering, 16104.
335387621:1000Wang, M., et al. 2021. Completion of neuronal remodeling prompts myelination along developing motor axon branches. Cellular Neurobiology, .
335084301:250Heller, G.J., et al. 2021. Waning efficacy in a long-term AAV-mediated gene therapy study in the murine model of Krabbe disease. Molecular Therapy, 1883-1902.
334995081:500Lee, J.I., et al. 2021. Purposeful Misalignment of Severed Nerve Stumps in a Standardized Transection Model Reveals Persistent Functional Deficit With Aberrant Neurofilament Distribution. Military Medicine, 696-703.
333037981:500Lee, J.I., et al. 2020. A novel nerve transection and repair method in mice: histomorphometric analysis of nerves, blood vessels, and muscles with functional recovery. Scientific Reports, 21637.
328079501:1000Babetto, E., et al. 2020. A glycolytic shift in Schwann cells supports injured axons. Nature Neuroscience, 1215-1228.
326728151:500Wüst, H.M., et al. 2020. Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination. Nucleic Acids Research, 8959-8976.
326414021:800Reed, C.B., et al. 2020. Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury. Journal of Neuroscience, 6165-6176.
32375064not listedWeinstock, N.I., et al. 2020. Macrophages Expressing GALC Improve Peripheral Krabbe Disease by a Mechanism Independent of Cross-Correction. Neuron, 65-81.
32209430not listedEshed-Eisenbach, Y., et al. 2020. Precise Spatiotemporal Control of Nodal Na+ Channel Clustering by Bone Morphogenetic Protein1/Tolloid-like Proteinases. Neuron, 806-815.
321430011:1000Govindappa, P.K., et al. 2020. An effective erythropoietin dose regimen protects against severe nerve injury-induced pathophysiological changes with improved neural gene expression and enhances functional recovery. International Immunopharmacology, 106330.
32000627not listedSmith, D.R., et al. 2020. Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. Tissue Engineering, 672-682.
33423486not listedSmith, D.R., et al. 2019. PLG bridge implantation in chronic SCI promotes axonal elongation and myelination. ACS Biomaterials Science & Engineering, 6679-6690.
312853391:250Park, J., et al. 2019. Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury. PNAS: USA, 14947-14954.
30901424not listedNoble, M., et al. 2019. 4-Aminopyridine as a Single Agent Diagnostic and Treatment for Severe Nerve Crush Injury. Military Medicine, 379-385.
306109181:250Dumont, C.M., et al. 2018. Aligned hydrogel tubes guide regeneration following spinal cord injury. Acta Biomaterialia, 312-322.
305353601:1000Belin, S., et al. 2018. Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of Congenital Hypomyelinating Neuropathy. Human Molecular Genetics, 1260-1273.
30229864not listedSmith, D.R., et al. 2018. Combinatorial lentiviral gene delivery of pro‐oligodendrogenic factors to improve myelination of regenerating axons after spinal cord injury. Biotechnology and Bioengineering, 155-167.
301844911:200Stratton, J.A., et al. 2018. Macrophages Regulate Schwann Cell Maturation after Nerve Injury. Cell Reports, 2561-2572.
293610541:2000Truch, K., et al. 2018. Analysis of the human SOX10 mutation Q377X in mice and its implications for genotype-phenotype correlation in SOX10-related human disease.. Human Molecular Genetics, 1078-1092.
287608621:100Assinck, P., et al. 2017. Myelinogenic Plasticity of Oligodendrocyte Precursor Cells following Spinal Cord Contusion Injury. The Journal of Neuroscience, 8635-8654.
281687031:1000Geary, M.B., et al. 2016. Erythropoietin accelerates functional recovery after moderate sciatic nerve crush injury. Muscle & Nerve, 143-151.
281396831:500Brügger, V., et al. 2016. Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration. Nature Communications, 14272.
275934861:1000Sundem, L., et al. 2016. Erythropoietin Enhanced Recovery After Traumatic Nerve Injury: Myelination and Localized Effects. The Journal of Hand Surgery, 999-1010.
Immunohistochemistry: Rat
PMID Dilution Publication
35434551not listedPark, H., et al. 2022. ACTL6a coordinates axonal caliber recognition and myelination in the peripheral nerve.. iScience, 104132.
345196411:300Nunes, G.D.F., et al. 2021. Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination. Elife, e66278.
325594591:100Assinck, P., et al. 2020. Transplantation of Skin Precursor-Derived Schwann Cells Yields Better Locomotor Outcomes and Reduces Bladder Pathology in Rats with Chronic Spinal Cord Injury. Stem Cell Reports, 140-155.
305110191:100Estrada, V., et al. 2018. Low-pressure micro-mechanical re-adaptation device sustainably and effectively improves locomotor recovery from complete spinal cord injury. Nature Communications Biology, 205.
301844911:200Stratton, J.A., et al. 2018. Macrophages Regulate Schwann Cell Maturation after Nerve Injury. Cell Reports, 2561-2572.
278899271:500Wegener, A., et al. 2016. Sp2 is the only glutamine-rich Specificity protein with minor impact on development and differentiation in myelinating glia. Journal of Neurochemistry, 245-256.
261214891:200Stratton, J.A., et al. 2015. The immunomodulatory properties of adult skin-derived precursor Schwann cells: implications for peripheral nerve injury therapy. European Journal of Neuroscience, 365-375.
273438031:1000Sapio, M.R., et al. 2009. Transcriptomic analyses of genes and tissues in inherited sensory neuropathies. Experimental Neurology, 375-395.
Immunohistochemistry: Swine
PMID Dilution Publication
338625961:1000Hellman, A., et al. 2021. Development of a common peroneal nerve injury model in domestic swine for the study of translational neuropathic pain treatments. Journal of Neurosurgery, 1-8.
Immunoprecipitation: Mouse
PMID Dilution Publication
29076578not listedVerPlank, J.J.S., et al. 2018. Impairment of protein degradation and proteasome function in hereditary neuropathies. Glia, 379-395.
Western Blot: Mouse
PMID Dilution Publication
363508841:5000Shackleford, G., et al. 2022. A New Mouse Model Of Charcot-Marie-Tooth 2J Neuropathy Replicates Human Axonopathy And Suggest Alteration In Axo-Glia Communication. PLoS Genetics, e1010477.
333368551:5000Jeanette, H., et al. 2020. YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration. Glia, 1061-1074.
326414021:1000Reed, C.B., et al. 2020. Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury. Journal of Neuroscience, 6165-6176.
314536491:4000Jha, M.K., et al. 2020. Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging. Glia, 161-177.
30901424not listedNoble, M., et al. 2019. 4-Aminopyridine as a Single Agent Diagnostic and Treatment for Severe Nerve Crush Injury. Military Medicine, 379-385.
305353601:5000Belin, S., et al. 2018. Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of Congenital Hypomyelinating Neuropathy. Human Molecular Genetics, 1260-1273.
29076578not listedVerPlank, J.J.S., et al. 2018. Impairment of protein degradation and proteasome function in hereditary neuropathies. Glia, 379-395.
291092391:2000Fazal, S.V., et al. 2017. Graded Elevation of c-Jun in Schwann Cells In Vivo: Gene Dosage Determines Effects on Development, Remyelination, Tumorigenesis, and Hypomyelination. Journal of Neuroscience, 12297-12313.
28484008not listedBeirowski,B., et al. 2017. mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells. PNAS: USA, E4261-E4270.
281396831:1000Brügger, V., et al. 2016. Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration. Nature Communications, 14272.
Western Blot: Rat
PMID Dilution Publication
25762662not listedDomenech-Estevez, E., et al. 2015. Distribution of Monocarboxylate Transporters in the Peripheral Nervous System Suggests Putative Roles in Lactate Shuttling and Myelination. The Journal of Neuroscience, 4151-4156.
Additional Publications: Unspecified
PMID Publication
31479164Forese, M.G., et al. 2020. Prostaglandin D2 synthase modulates macrophage activity and accumulation in injured peripheral nerves. Glia, 95-110.

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