Western blot of rat kidney lysate showing specific immunolabeling of the ~24 kDa TFAM protein.

Western blot of rat kidney lysate showing specific immunolabeling of the ~24 kDa TFAM protein.

from PhosphoSolutions

Anti-TFAM (Transcription Factor A, motochondrial) (2001-TFAM)

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Product Details


Details

Volume: 100 µL (Standard), 25 µL (Trial Size)

Concentration: Lot Specific

Clonality: Polyclonal

Form: Neat Serum

Host Species: Rabbit

Species Reactivity: Human, Mouse, Rat

Applications: WB

Immunogen: Native recombinant mouse TFAM protein with c-terminal 6-his tag

Target Description: Mitochondrial Transcription Factor A (TFAM) is a key activator of mitochondrial (mt) DNA transcription as well as a participant in mitochondrial genome replication. mtDNA is highly susceptible to oxidative stress leading to mitochondrial dysfunction. Overexpression of TFAM has been implicated in the amelioration of age dependent impairment of brain functions through the prevention of oxidative stress and mitochondrial dysfunction in microglia (Hayashi et al., 2008). More recently, TFAM overexpression has been shown to potentially reduce oxidative stress in motor neurons and delay onset of amyotrophic lateral sclerosis (ALS) in ALS model mice (Morimoto et al., 2012).

Gene ID: TFAM

Antibody Registry ID (RRID): AB_2492259

Physical State: Liquid

Conjugate: Unconjugated

Buffer: 100 ul serum

Validation and Application Notes

Molecular Weight: 24

Storage

-20 C

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.


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