Volume: 100 µL (Standard), 25 µL (Trial Size)
Concentration: Lot Specific
Form: Neat Serum
Host Species: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Native recombinant mouse TFAM protein with c-terminal 6-his tag
Target Description: Mitochondrial Transcription Factor A (TFAM) is a key activator of mitochondrial (mt) DNA transcription as well as a participant in mitochondrial genome replication. mtDNA is highly susceptible to oxidative stress leading to mitochondrial dysfunction. Overexpression of TFAM has been implicated in the amelioration of age dependent impairment of brain functions through the prevention of oxidative stress and mitochondrial dysfunction in microglia (Hayashi et al., 2008). More recently, TFAM overexpression has been shown to potentially reduce oxidative stress in motor neurons and delay onset of amyotrophic lateral sclerosis (ALS) in ALS model mice (Morimoto et al., 2012).
Gene ID: TFAM
Antibody Registry ID (RRID): AB_2492259
Physical State: Liquid
Buffer: 100 ul serum
Validation and Application Notes
Molecular Weight: 24
Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.