Anti-TREM2 Antibody

Name: Anti-TREM2 Antibody
Brand: Aves Labs
SKU: TREM2-0100
Price: 410.0 USD
Availability: InStock

from Aves Labs Datasheet Trial Size

Our anti-TREM2 chicken primary antibody from AvesLabs is manufactured in-house. It detects TREM2, and is purified. It is provided in liquid form.

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Western blot of rat brain membrane lysate using chicken α-TREM2 showing specific immunolabeling of the endogenous TREM2 at ~35kDa.

Immunofluorescence of TREM2-FLAG transfected COS-7 cells using chicken α-TREM2 (green) and mouse α-flag tag (red). Yellow/orange staining shows 100% correspondence between the two antibodies for recognition of transfected cells. Blue staining is DAPI and stains nuclei of both transfected and untransfected cells.

Volume: 500 µL

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Product Details

Target

TREM2

Target Description

Triggering receptor expressed on myeloid cells 2, TREM2, is a type I transmembrane innate immune receptor predominantly expressed by microglia in the central nervous system and is genetically linked to the risk for Alzheimer’s disease (Schmid, C.D., et al., 2002). TREM2 has been shown to be a specific marker for alternatively activated microglia known as M2 cells (Cherry, J.D. et al., 2014). TREM2 binds to its adaptor, DNAX-activating protein (DAP12) on the surface of microglia to enact innate immune responses and downstream cellular responses or signaling pathways (Jay,T.R, et al., 2017). TREM2 has important roles in microglial phagocytosis of apoptotic neurons, damaged myelin, and amyloid plaques (Gratuze, M., et al., 2018). In early brain development, TREM2 is essential for synaptic pruning (Filipello, F. et al., 2018).

Antigen

Purified recombinant extracellular domain of human TREM2 (Uniprot Q9NZC2) expressed in E.Coli(Human)

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

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UniProt Details

UniProt (Human): Q9NZC2
UniProt (Immunogen Species): Q9NZC2

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Anti-TREM2 Antibody

Our anti-TREM2 chicken primary antibody from AvesLabs is manufactured in-house. It detects TREM2, and is purified. It is provided in liquid form.