Adult rat hippocampus immunohistochemistry.

Adult rat hippocampus immunohistochemistry.

Adult rat brain membrane immunoblot.

Adult rat brain membrane immunoblot.

Immunoblot on adult mouse brain membranes from two wild-type mice (MBM-WT) and one Kv2.1 knockout (MBM-Kv2.1-KO) mouse. Samples courtesy of Dr. Jeanne Nerbonne, Washington University School of Medicine.

Immunoblot on adult mouse brain membranes from two wild-type mice (MBM-WT) and one Kv2.1 knockout (MBM-Kv2.1-KO) mouse. Samples courtesy of Dr. Jeanne Nerbonne, Washington University School of Medicine.

Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)].

Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)].

from NeuroMab

Kv2.1 K+ channel (7x-014)

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Product Details | ↓ Citations



Volume: Purified: 100 µL; Purified Trial: 20 µL; TC Supernatant: 5 mL

Concentration: Purified: 1 mg/mL; TC Supernatant: Lot Specific

Clonality: Monoclonal

Form: Purified and TC Supernatant Available (select your preferred form, size and quantity before clicking "Add to Cart")

Host Species: Mouse

Immunogen: Synthetic peptide amino acids 837-853 (HMLPGGGAHGSTRDQSI, cytoplasmic Cterminus) of rat Kv2.1 (also known as Potassium voltage-gated channel subfamily B member 1, Delayed rectifier potassium channel 1, DRK1, Kcnb1 and Shab, accession number P15387)
Mouse: 100% identity (17/17 amino acids identical)
Human: 88% identity (15/17 amino acids identical, RVLPGGGAHGSTRDQSI)

Target Description: Kv 2.1 K+ channel (Potassium voltage-gated channel subfamily B member 1), which is encoded by KCNB1 gene, is a member of the Potassium voltage-gated channel familly. This protein, mainly expressed in the central nervous system, functions as a delayed rectifier. Indeed, it regulates the action potential (AP) repolarization as well as duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells. Kv2.1 K+ channel switches between open or closed conformation in response to the voltage difference across the membrane. This process directs the voltage-dependent potassium ion permeability of excitable membranes, which lets potassium ions pass in accordance with their electrochemical gradient. Kv2.1 K+ channel is widely used as a marker to measure membrane excitability in hippocampal neurons.

Gene ID: Kcnb1

Antibody Registry ID (RRID): AB_10673392

Physical State: Liquid

Validation and Application Notes

Molecular Weight: 105-125 kDa(varies with cell background due to phosphorylation)

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.


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