Immunohistochemical presence of tau in neurofibrillary tangles in cortical neurons of an Alzheimer's Disease patient.  Anti-Tau antibody (Aves Labs, 1:10,000) was incubated with formalin-fixed, paraffin-embedded sectioned material from Alzheimer's brains.  Primary antibody was visualized with HRP-labeled goat anti-chicken IgY.  Dr. Randy Woltjer, Oregon Health & Sciences University.

Immunohistochemical presence of tau in neurofibrillary tangles in cortical neurons of an Alzheimer's Disease patient. Anti-Tau antibody (Aves Labs, 1:10,000) was incubated with formalin-fixed, paraffin-embedded sectioned material from Alzheimer's brains. Primary antibody was visualized with HRP-labeled goat anti-chicken IgY. Dr. Randy Woltjer, Oregon Health & Sciences University.

Immunohistochemical presence of tau in a neurofibrillary tangle in the remnant of a cortical neuron of an Alzheimer's Disease patient.  Anti-Tau antibody (Aves Labs, 1:10,000) was incubated with formalin-fixed, paraffin-embedded sectioned material from Alzheimer's brains.  Primary antibody was visualized with HRP-labeled goat anti-chicken IgY.  Dr. Randy Woltjer, Oregon Health & Sciences University.

Immunohistochemical presence of tau in a neurofibrillary tangle in the remnant of a cortical neuron of an Alzheimer's Disease patient. Anti-Tau antibody (Aves Labs, 1:10,000) was incubated with formalin-fixed, paraffin-embedded sectioned material from Alzheimer's brains. Primary antibody was visualized with HRP-labeled goat anti-chicken IgY. Dr. Randy Woltjer, Oregon Health & Sciences University.

Immunohistochemical presence of tau in a neurofibrillary tangles in cortical neurons of an Alzheimer's Disease patient.  Anti-Tau antibody (Aves Labs, 1:10,000) was incubated with formalin-fixed, paraffin-embedded sectioned material from Alzheimer's brains.  Primary antibody was visualized with HRP-labeled goat anti-chicken IgY.  Dr. Randy Woltjer, Oregon Health & Sciences University.

Immunohistochemical presence of tau in a neurofibrillary tangles in cortical neurons of an Alzheimer's Disease patient. Anti-Tau antibody (Aves Labs, 1:10,000) was incubated with formalin-fixed, paraffin-embedded sectioned material from Alzheimer's brains. Primary antibody was visualized with HRP-labeled goat anti-chicken IgY. Dr. Randy Woltjer, Oregon Health & Sciences University.

Immunohistochemical presence of tau in a neurofibrillary tangles in cortical neurons of an Alzheimer's Disease patient.  Anti-Tau antibody (Aves Labs, 1:10,000) was incubated with formalin-fixed, paraffin-embedded sectioned material from Alzheimer's brains.  Primary antibody was visualized with HRP-labeled goat anti-chicken IgY.  Dr. Randy Woltjer, Oregon Health & Sciences University.

Immunohistochemical presence of tau in a neurofibrillary tangles in cortical neurons of an Alzheimer's Disease patient. Anti-Tau antibody (Aves Labs, 1:10,000) was incubated with formalin-fixed, paraffin-embedded sectioned material from Alzheimer's brains. Primary antibody was visualized with HRP-labeled goat anti-chicken IgY. Dr. Randy Woltjer, Oregon Health & Sciences University.

Anti-Tau (TAU)

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Details

Chickens were immunized with two synthetic peptide / keyhole limpet hemocyanin (KLH) conjugates. These synthetic peptides corresponded to different and nonphosphorylated regions of the Tau gene product, but are shared between the human (NP_05819, NCBI) and mouse (P01637, NCBI) sequences. After repeated injections, immune eggs were collected, and the IgY fractions were purified from the yolks. These IgY fractions were then affinity-purified using a peptide column, and the concentrations of the eluates adjusted to 200 µg/mL. Finally, equal volumes of both of these affinity-purified anti-peptide antibodies were mixed, and the preparation was filter-sterilized.

Volume: 1000 µL

Concentration: 200 µg/mL

Clonality: Polyclonal

Host Species: Chicken

Species Reactivity: Human, Mouse, Rat

Applications: ICC, IHC

Protein Name / Synonyms: Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)

Gene ID: MAPT MAPTL MTBT1 TAU

Antibody Registry ID (RRID): AB_2313563

Physical State: Liquid

Validation and Application Notes

IHC Dilution Range: 1:5000-1:10000

Quality Control

Both of these anti-peptide antibodies were analyzed by immunohisto-chemistry (at a dilution of 1:20000) using fluorescein-labeled goat anti-chicken IgY (1:500 dilution, Aves Labs Cat.# F-1005) as the secondary reagent.

Storage

Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least 12 months (provided they remain sterile). Do not freeze these antibodies unless you want to store them for longer periods of time. Note, however, that each time an antibody preparation is frozen, about half of its binding activity is lost.

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.


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Citations

    Peripheral Nervous System Suggests Putative Roles in

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