Details

Concentration: 1 mg/mL

Clonality: Monoclonal

Form: Purified

Host Species: Mouse

Immunogen: Fusion protein amino acids 493-560 (cytoplasmic C-terminus) of rat VGlut1 (also known as Vesicular glutamate transporter 1, Brain-specific Na(+)-dependent inorganic phosphate cotransporter, Bnpi, Solute carrier family 17 member 7 and Slc17a7, accession number Q62634)
Mouse: 97% identity (66/68 amino acids identical)
Human: 95% identity (65/68 amino acids identical)
50% identity with VGlut2 or VGlut3

Gene ID: Slc17a7 Bnpi Vglut1

Antibody Registry ID (RRID): AB_2187693

Physical State: Liquid

Validation and Application Notes

Expected Banding Pattern: 52 kDa

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.

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Citations

• Brechet A, Buchert R, Schwenk J, Boudkkazi S, Zolles G, Siquier-Pernet K, Schaber I, Bildl W, Saadi A, Bole-Feysot C, Nitschke P, Reis A, Sticht H, Al-Sanna'a N, Rolfs A, Kulik A, Schulte U, Colleaux L, Abou Jamra R, Fakler B. (2017), 'AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability..' Nature Communications. 10.1038/ncomms15910.
• Gong J, Lai Y, Li X, Wang M, Leitz J, Hu Y, Zhang Y, Choi UB, Cipriano D, Pfuetzner RA, Südhof TC, Yang X, Brunger AT, Diao J. (2016), 'C-terminal domain of mammalian complexin-1 localizes to highly curved membranes..' Proceedings of the National Academy of Science of the United States of America. 10.1073/pnas.1609917113.
• Park KA, Ribic A, Laage Gaupp FM, Coman D, Huang Y, Dulla CG, Hyder F, Biederer T. (2016), 'Excitatory Synaptic Drive and Feedforward Inhibition in the Hippocampal CA3 Circuit Are Regulated by SynCAM 1..' Journal of Neuroscience. 10.1523/JNEUROSCI.0189-16.2016.
• Krishnaswamy A, Yamagata M, Duan X, Hong YK, Sanes JR. (2015), 'Sidekick 2 directs formation of a retinal circuit that detects differential motion..' Nature. 10.1038/nature14682.
• Li H, Harlow ML. (2015), 'Individual synaptic vesicles from the electroplaque of Torpedo californica, a classic cholinergic synapse, also contain transporters for glutamate and ATP..' Physiological Reports. 10.1002/phy2.206.
• Su J, Gorse K, Ramirez F, Fox MA. (2010), 'Collagen XIX is expressed by interneurons and contributes to the formation of hippocampal synapses..' Journal of Comparative Neurology. 10.1002/cne.22228.
• Jiang YQ, Zaaimi B, Martin JH. (2016), 'Competition with Primary Sensory Afferents Drives Remodeling of Corticospinal Axons in Mature Spinal Motor Circuits..' Journal of Neuroscience. 10.1523/JNEUROSCI.3441-15.2016.
• Slater PG, Noches V, Gysling K. (2016), 'Corticotropin-releasing factor type-2 receptor and corticotropin-releasing factor-binding protein coexist in rat ventral tegmental area nerve terminals originated in the lateral hypothalamic area..' European Journal of Neuroscience. 10.1111/ejn.13113.
• Sáez-Orellana F, Godoy PA, Bastidas CY, Silva-Grecchi T, Guzmán L, Aguayo LG, Fuentealba J (2015), 'ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxicity induced by soluble oligomers of β-amyloid peptide in hippocampal neurons..' Neuropharmacology. 10.1016/j.neuropharm.2015.04.005.
• Son SM, Nam DW, Cha MY, Kim KH, Byun J, Ryu H, Mook-Jung I. (2015), 'Thrombospondin-1 prevents amyloid beta-mediated synaptic pathology in Alzheimer's disease..' Neurobiology of Aging. 10.1016/j.neurobiolaging.2015.09.005.
• Béliveau E, Tremblay C, Aubry-Lafontaine É, Paris-Robidas S, Delay C, Robinson C, Ferguson L, Rajput AH, Rajput A, Calon F. (2015), 'Accumulation of amyloid-β in the cerebellar cortex of essential tremor patients..' Neurobiology of Disease. 10.1016/j.nbd.2015.07.016.
• Tempia F, Hoxha E, Negro G, Alshammari MA, Alshammari TK, Panova-Elektronova N, Laezza F. (2015), 'Parallel fiber to Purkinje cell synaptic impairment in a mouse model of spinocerebellar ataxia type 27..' Frontiers in Neuroscience. 10.3389/fncel.2015.00205.
• Katiyar R, Weissgerber P, Roth E, Dörr J, Sothilingam V, Garcia Garrido M, Beck SC, Seeliger MW, Beck A, Schmitz F, Flockerzi V. (2015), 'Influence of the β2-Subunit of L-Type Voltage-Gated Cav Channels on the Structural and Functional Development of Photoreceptor Ribbon Synapses..' Investigative Ophthalmology & Visual Science. 10.1167/iovs.15-16654.
• Niedringhaus M, Dumitru R, Mabb AM, Wang Y, Philpot BD, Allbritton NL, Taylor AM. (2015), 'Transferable neuronal mini-cultures to accelerate screening in primary and induced pluripotent stem cell-derived neurons..' Scientific Reports. 10.1038/srep08353.
• Caminos E, Vaquero CF, Martinez-Galan JR. (2015), 'Relationship between rat retinal degeneration and potassium channel KCNQ5 expression..' Experimental Eye Research. 10.1016/j.exer.2014.12.009.
• Sotoca JV, Alvarado JC, Fuentes-Santamaría V, Martinez-Galan JR, Caminos E. (2014), 'Hearing impairment in the P23H-1 retinal degeneration rat model..' Frontiers in Neuroscience. 10.3389/fnins.2014.00297.
• Demyanenko GP, Mohan V, Zhang X, Brennaman LH, Dharbal KE, Tran TS, Manis PB, Maness PF. (2014), 'Neural cell adhesion molecule NrCAM regulates Semaphorin 3F-induced dendritic spine remodeling..' Journal of Neuroscience. 10.1523/JNEUROSCI.1774-14.2014.
• Plowey ED, Johnson JW, Steer E, Zhu W, Eisenberg DA, Valentino NM, Liu YJ, Chu CT. (2014), 'Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration..' Biochimica et Biophysica Acta. 10.1016/j.bbadis.2014.05.016.
• Muntané G, Horvath JE, Hof PR, Ely JJ, Hopkins WD, Raghanti MA, Lewandowski AH, Wray GA, Sherwood CC. (2014), 'Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission..' Cereb Cortex. 10.1093/cercor/bht354.
• Michalakis S, Shaltiel L, Sothilingam V, Koch S, Schludi V, Krause S, Zeitz C, Audo I, Lancelot ME, Hamel C, Meunier I, Preising MN, Friedburg C, Lorenz B, Zabouri N, Haverkamp S, Garcia Garrido M, Tanimoto N, Seeliger MW, Biel M, Wahl-Schott CA. (2014), 'Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2..' Human Molecular Genetics. 10.1093/hmg/ddt541.
• Yuan Y, Shi F, Yin Y, Tong M, Lang H, Polley DB, Liberman MC, Edge AS. (2014), 'Ouabain-induced cochlear nerve degeneration: synaptic loss and plasticity in a mouse model of auditory neuropathy..' Journal of the Association for Research in Otolaryngology. 10.1007/s10162-013-0419-7.
• Gaier ED, Miller MB, Ralle M, Aryal D, Wetsel WC, Mains RE, Eipper BA. (2013), 'Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity..' Journal of Neurochemistry. 10.1111/jnc.12438.
• Song YS, Lee HJ, Prosselkov P, Itohara S, Kim E. (2013), 'Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses..' Journal of Cell Science. 10.1242/jcs.129718.
• Ribic A, Liu X, Crair MC, Biederer T. (2014), 'Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1..' Journal of Comparative Neurology. 10.1002/cne.23452.
• Sherry DM, Blackburn BA. (2014), 'P-Rex2, a Rac-guanine nucleotide exchange factor, is expressed selectively in ribbon synaptic terminals of the mouse retina..' BMC Neuroscience. 10.1186/1471-2202-14-70.
• Wahl S, Katiyar R, Schmitz F. (2014), 'A local, periactive zone endocytic machinery at photoreceptor synapses in close vicinity to synaptic ribbons..' Journal of Neuroscience. 10.1523/JNEUROSCI.5048-12.2013.
• Seabrook TA, El-Danaf RN, Krahe TE, Fox MA, Guido W. (2014), 'Retinal input regulates the timing of corticogeniculate innervation..' Journal of Neuroscience. 10.1523/JNEUROSCI.5271-12.2013.
• Li L, Hanahan D. (2013), 'Hijacking the neuronal NMDAR signaling circuit to promote tumor growth and invasion..' Cell. 10.1016/j.cell.2013.02.051.
• Bray JG, Reyes KC, Roberts AJ, Ransohoff RM, Gruol DL. (2013), 'Synaptic plasticity in the hippocampus shows resistance to acute ethanol exposure in transgenic mice with astrocyte-targeted enhanced CCL2 expression..' Neuropharmacology. 10.1016/j.neuropharm.2012.11.007.
• Arons MH, Thynne CJ, Grabrucker AM, Li D, Schoen M, Cheyne JE, Boeckers TM, Montgomery JM, Garner CC. (2012), 'Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling..' Journal of Neuroscience. 10.1523/JNEUROSCI.2215-12.2012.
• Loriol C, Khayachi A, Poupon G, Gwizdek C, Martin S. (2013), 'Activity-dependent regulation of the sumoylation machinery in rat hippocampal neurons..' Biology of the Cell. 10.1111/boc.201200016.
• Tan AM, Chakrabarty S, Kimura H, Martin JH. (2012), 'Selective corticospinal tract injury in the rat induces primary afferent fiber sprouting in the spinal cord and hyperreflexia..' Journal of Neuroscience. 10.1523/JNEUROSCI.6451-11.2012.
• Inestrosa NC, Tapia-Rojas C, Griffith TN, Carvajal FJ, Benito MJ, Rivera-Dictter A, Alvarez AR, Serrano FG, Hancke JL, Burgos PV, Parodi J, Varela-Nallar L. (2011), 'Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: a possible effect on APP processing..' Translational Psychiatry. 10.1038/tp.2011.19.
• Nguyen MV, Du F, Felice CA, Shan X, Nigam A, Mandel G, Robinson JK, Ballas N. (2012), 'MeCP2 is critical for maintaining mature neuronal networks and global brain anatomy during late stages of postnatal brain development and in the mature adult brain..' Journal of Neuroscience. 10.1523/JNEUROSCI.1316-12.2012.
• Liu J, Koscielska KA, Cao Z, Hulsizer S, Grace N, Mitchell G, Nacey C, Githinji J, McGee J, Garcia-Arocena D, Hagerman RJ, Nolta J, Pessah IN, Hagerman PJ. (2012), 'Signaling defects in iPSC-derived fragile X premutation neurons..' Human Molecular Genetics. 10.1093/hmg/dds207.
• Nelson TE, Olde Engberink A, Hernandez R, Puro A, Huitron-Resendiz S, Hao C, De Graan PN, Gruol DL. (2012), 'Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6..' Brain, Behavior, and Immunity. 10.1016/j.bbi.2012.05.005.
• Tsetsenis T, Younts TJ, Chiu CQ, Kaeser PS, Castillo PE, Südhof TC. (2011), 'Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning..' Proceedings of the National Academy of Science of the United States of America 2. 10.1073/pnas.1112237108.
• Larsson M, Sawada K, Morland C, Hiasa M, Ormel L, Moriyama Y, Gundersen V. (2012), 'Functional and anatomical identification of a vesicular transporter mediating neuronal ATP release..' Cereb Cortex. 10.1093/cercor/bhr203.
• Koeppen AH, Davis AN, Morral JA. (2011), 'The cerebellar component of Friedreich's ataxia..' Acta Neuropathologica. 10.1007/s00401-011-0844-9.
• Mutch SA, Kensel-Hammes P, Gadd JC, Fujimoto BS, Allen RW, Schiro PG, Lorenz RM, Kuyper CL, Kuo JS, Bajjalieh SM, Chiu DT. (2011), 'Protein quantification at the single vesicle level reveals that a subset of synaptic vesicle proteins are trafficked with high precision..' Journal of Neuroscience. 10.1523/JNEUROSCI.3805-10.2011.
• Takahashi H, Arstikaitis P, Prasad T, Bartlett TE, Wang YT, Murphy TH, Craig AM. (2011), 'Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex..' Neuron. 10.1016/j.neuron.2010.12.024.
• Micheva KD, Busse B, Weiler NC, O'Rourke N, Smith SJ. (2010), 'Single-synapse analysis of a diverse synapse population: proteomic imaging methods and markers..' Neuron. 10.1016/j.neuron.2010.09.024.
• Varela-Nallar L, Alfaro IE, Serrano FG, Parodi J, Inestrosa NC. (2010), 'Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses..' Proceedings of the National Academy of Science of the United States of America. 10.1073/pnas.1010011107.
• Liu J, Chang L, Roselli F, Almeida OF, Gao X, Wang X, Yew DT, Wu Y. (2012), 'Amyloid-β induces caspase-dependent loss of PSD-95 and synaptophysin through NMDA receptors..' Journal of Alzheimer's Disease. 10.3233/JAD-2010-100948.
• Platel JC, Dave KA, Gordon V, Lacar B, Rubio ME, Bordey A. (2010), 'NMDA receptors activated by subventricular zone astrocytic glutamate are critical for neuroblast survival prior to entering a synaptic network..' Neuron. 10.1016/j.neuron.2010.03.009.
• Filiou MD, Bisle B, Reckow S, Teplytska L, Maccarrone G, Turck CW. (2010), 'Profiling of mouse synaptosome proteome and phosphoproteome by IEF..' Electrophoresis. 10.1002/elps.200900647.
• Perez de Arce K, Varela-Nallar L, Farias O, Cifuentes A, Bull P, Couch BA, Koleske AJ, Inestrosa NC, Alvarez AR. (2010), 'Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation..' Journal of Neuroscience. 10.1523/JNEUROSCI.2024-09.2010.
• Garcia-Pino E, Caminos E, Juiz JM. (2010), 'KCNQ5 reaches synaptic endings in the auditory brainstem at hearing onset and targeting maintenance is activity-dependent..' Journal of Comparative Neurology. 10.1002/cne.22276.
• Varela-Nallar L, Grabowski CP, Alfaro IE, Alvarez AR, Inestrosa NC. (2009), 'Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function..' Neural Development. 10.1186/1749-8104-4-41.
• Linhoff MW, Laurén J, Cassidy RM, Dobie FA, Takahashi H, Nygaard HB, Airaksinen MS, Strittmatter SM, Craig AM. (2009), 'An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers..' Neuron. 10.1016/j.neuron.2009.01.017.
• Mathur BN, Deutch AY. (2009), 'Rat meningeal and brain microvasculature pericytes co-express the vesicular glutamate transporters 2 and 3..' Neuroscience Letters. 10.1016/j.neulet.2008.01.082.

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