Volume: Purified: 100 µL; Purified Trial: 20 µL; TC Supernatant: 5 mL

Concentration: Purified: 1 mg/mL; TC Supernatant: Lot Specific

Clonality: Monoclonal

Form: Purified and TC Supernatant Available (select your preferred form, size and quantity before clicking "Add to Cart")

Host Species: Mouse

Immunogen: Fusion protein amino acids 493-560 (cytoplasmic C-terminus) of rat VGlut1 (also known as Vesicular glutamate transporter 1, Brain-specific Na(+)-dependent inorganic phosphate cotransporter, Bnpi, Solute carrier family 17 member 7 and Slc17a7, accession number Q62634)
Mouse: 97% identity (66/68 amino acids identical)
Human: 95% identity (65/68 amino acids identical)
50% identity with VGlut2 or VGlut3

Target Description: Vesicular glutamate transporter 1 (Vglut1) is encoded by the gene Slc17a7 and belongs to the vesicular glutamate transporter family. Vglut1 is expressed in glutamatergic neurons in brain regions including the cerebellum, cerebral cortex and hippocampus at synaptic vesicles. Isoform 2 is expressed in retinal. Vglut1 functions to uptake glutamate into synaptic vesicles in excitatory neural cells. Altered expression of Vglut1 has been implicated in several neurological and psychiatric diseases including Alzheimer’s disease, Parkinson’s disease, epilepsy and schizophrenia.

Gene ID: Slc17a7 Bnpi Vglut1

Antibody Registry ID (RRID): AB_2187693

Physical State: Liquid

Validation and Application Notes

Molecular Weight: 52 kDa

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.

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Citations

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