Anti-CASPR/Neurexin IV Antibody (K65/35)


Primary Antibody
Human, Mouse, Rat
K65/35
IHC, IP, WB
Mouse
Purified
Cntnap1 Caspr Nrxn4
220 kDa

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Anti-CASPR/Neurexin IV Antibody
SKU: 75-001

Volume: 100 µL
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Product Specific References for Applications and Species

Immunocytochemistry: Human
PMID Dilution Publication
354177461:400Otani, Y., et al. 2022. Influence of Novel Readthrough Agents on Myelin Protein Zero Translation in the Peripheral Nervous System. Neuropharmacology, 109059.
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285126491:40Stratton, J.A., et al. 2017. Purification and Characterization of Schwann Cells from Adult Human Skin and Nerve. eNeuro, .
Immunocytochemistry: Mouse
PMID Dilution Publication
356721491:1000Liu, H., et al. 2022. Direct Observation of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels. The Journal of Neuroscience, 5482-5498.
32125730not listedJarjour, A.A., et al. 2020. The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2. Glia, 1840-1858.
29138759not listedBrowne, L., et al. 2017. Identification of persistent and resurgent sodium currents in spiral ganglion neurons cultured from the mouse cochlea.. Eneuro, .
264069151:200Brügger, V., et al. 2015. HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins.. PLoS Biology, e1002258.
25362473not listedHo, T.S., et al. 2015. A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier.. Nature Neuroscience, 1664-72.
192618671:1000Sharkey, L.M., et al. 2009. The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking.. Journal of Neuroscience, 2733-2741.
190132471:500O'Malley, H.A., et al. 2009. Loss of Na+ channel β2 subunits is neuroprotective in a mouse model of multiple sclerosis. . Molecular and Cellular Neuroscience, 143-155.
Immunohistochemistry: Gerbil
PMID Dilution Publication
27110919not listedKo, K.W., et al. 2016. Serotonin modulates spike probability in the axon initial segment through HCN channels. Nature Neuroscience, 826-834.
265561761:1000Seidl, A.H., et al. 2016. Systematic and differential myelination of axon collaterals in the mammalian auditory brainstem.. Glia, 487-494.
Immunohistochemistry: Human
PMID Dilution Publication
20838243not listedHowell, O.W., et al. 2010. Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis.. Journal of Neuropathology & Experimental Neurology, 1017-1033.
Immunohistochemistry: Mouse
PMID Dilution Publication
362735071:200Takahashi, K., et al. 2022. Brexpiprazole Prevents Colitis-Induced Depressive-Like Behavior Through Myelination in the Prefrontal Cortex. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 110666.
359524941:400Silva Oliveira Junior, M., et al. 2022. Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations. EBioMedicine, 104204.
357260311:200Malara, M., et al. 2022. SHANK3 Deficiency Leads to Myelin Defects in the Central and Peripheral Nervous System. Cellular and Molecular Life Sciences, 371.
352465351:500Meschkat, M., et al. 2022. White matter integrity in mice requires continuous myelin synthesis at the inner tongue. Nature communications, 1163.
351233261:200Takahashi, K., et al. 2022. Antidepressant effects of Enterococcus faecalis 2001 through the regulation of prefrontal cortical myelination via the enhancement of CREB/BDNF and NF-κB p65/LIF/STAT3 pathways in olfactory bulbectomized mice. Journal of Psychiatric Research, 137-148.
34844642not listedHay, C.M., et al. 2021. The oligodendrocyte-enriched orphan G protein-coupled receptor Gpr62 is dispensable for central nervous system myelination. Neural development, 16(1), pp.1-13.. Neural development, .
346483301:100Lezmy, J., et al. 2021. Astrocyte Ca 2+-evoked ATP release regulates myelinated axon excitability and conduction speed. Science, eabh2858.
336051751:100Nonaka, M., et al. 2021. Behavioral and Myelin-Related Abnormalities after Blast-Induced Mild Traumatic Brain Injury in Mice. Journal of Neurotrauma, 1551-1571.
335637231:100Prades, S., et al. 2021. Functional P2X 7 Receptors in the Auditory Nerve of Hearing Rodents Localize Exclusively to Peripheral Glia. Journal of Neuroscience, 2615-2629.
334728651:200Alam, M.M., et al. 2021. Deficiency of Microglial Autophagy Increases the Density of Oligodendrocytes and Susceptibility to Severe Forms of Seizures. eNeuro, .
334720751:200Cullen, C.L., et al. 2021. Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain. Cell Reports, 108641.
348253951:100Newville, J., et al. 2020. Persistent myelin abnormalities in a third trimester‐equivalent mouse model of fetal alcohol spectrum disorder. . Alcoholism: Clinical and Experimental Research, 77-86.
333350321:100Yang, S.M., et al. 2020. Neuron class-specific responses govern adaptive myelin remodeling in the neocortex. Science, eabd2109.
325577781:200Ferreira, S., et al. 2020. Amyloidosis is associated with thicker myelin and increased oligodendrogenesis in the adult mouse brain. . Journal of neuroscience research, 1905-1932.
321702071:400Otani, Y., et al. 2020. Upregulation of large myelin protein zero leads to Charcot-Marie-Tooth disease-like neuropathy in mice. Communications Biology, 121.
317695051:100Yu, Y., et al. 2020. Microglial Hv1 proton channels promote white matter injuries after chronic hypoperfusion in mice. Journal of Neurochemistry, 350-367.
319336261:500Alshammari, M.A., et al. 2019. Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model. Neural Plasticity, 4893103.
31839007not listedAziz, N.M., et al. 2019. Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of Down syndrome. Journal of Neurodevelopmental Disorders, 35.
316411271:1000Djannatian, M., et al. 2019. Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS. Nature Communications, 4794.
312857741:100Wang, M., et al. 2019. Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease. Theranostics, 4474-4493.
293008911:300Scott, R., et al. 2019. Loss of Cntnap2 Causes Axonal Excitability Deficits, Developmental Delay in Cortical Myelination, and Abnormal Stereotyped Motor Behavior. Cereb Cortex, 586-597.
305555561:100Qin, C., et al. 2018. Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway. Theranostics, 5434-5451.
30240044not listedLiu, Y., et al. 2018. Distinct patterns of glia repair and remyelination in antibody‐mediated demyelination models of multiple sclerosis and neuromyelitis optica. . Glia, 2575-2588.
301490501:500Smith, M.A., et al. 2018. Nodes of Ranvier in Glaucoma. Neuroscience, 104-118.
296640211:250Srivastava, T., et al. 2018. A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors. Journal of Clinical Investigation, 2025-2041.
295560311:500Hill, R.A., et al. 2018. Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain. Nature Neuroscience, 683-695.
29431744not listedHe, X., et al. 2018. A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. Nature Medicine, 338-351.
287222341:50Manso, Y., et al. 2018. Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease. Glia, 34-46.
285569451:500Davidson, N.L., et al. 2017. Leukemia/lymphoma-related factor (LRF) exhibits stage- and context-dependent transcriptional controls in the oligodendrocyte lineage and modulates remyelination. Journal of Neuroscience Research, 2391-2408.
281936891:100Furusho, M., et al. 2017. Signaling by FGF Receptor 2, Not FGF Receptor 1, Regulates Myelin Thickness through Activation of ERK1/2-MAPK, Which Promotes mTORC1 Activity in an Akt-Independent Manner. Journal of Neuroscience, 2931-2946.
281740591:1000Oshitari, T., et al. 2017. Alterations of myelin morphology and oligodendrocyte development in early stage of Alzheimer's disease mouse model. Neuroscience Letters, 102-106.
28123356not listedYoshimura, T., et al. 2017. Developmental Changes in Expression of βIV Spectrin Splice Variants at Axon Initial Segments and Nodes of Ranvier. Frontiers in cellular neuroscience, 304.
277757201:100Goebbels, S., et al. 2017. A neuronal PI(3,4,5)P 3-dependent program of oligodendrocyte precursor recruitment and myelination. Nature Neuroscience, 10-15.
274482451:50Serwanski, D.R., et al. 2017. Heterogeneity of astrocyte and NG2 cell insertion at the node of ranvier.. Journal of Comparative Neurology, .
27581456not listedMarin, M.A., et al. 2016. Reassembly of excitable domains after CNS axon regeneration. Journal of Neuroscience, 36(35), pp.9148-9160.. Journal of Neuroscience, 9148-9160.
269090211:500Alshammari, M.A., et al. 2016. Improved methods for fluorescence microscopy detection of macromolecules at the axon initial segment. . Frontiers in cellular neuroscience, 5.
267249021:200Kawabata, S., et al. 2016. Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury.. Stem Cell Reports, .
26203142not listedZollinger, D.R., et al. 2015. The polarity protein Pals1 regulates radial sorting of axons. . Journal of Neuroscience, 10474-10484.
259482591:1000Hirono, M., et al. 2015. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.. Journal of Neuroscience, 7082-7094.
25362471not listedChang, K.J., et al. 2014. Glial ankyrins facilitate paranodal axoglial junction assembly.. Nature Neuroscience, 1673-81.
253197081:100Xing, Y.L., et al. 2014. Adult neural precursor cells from the subventricular zone contribute significantly to oligodendrocyte regeneration and remyelination. . Journal of Neuroscience, 14128-14146.
21958379not listedDuflocq, A., et al. 2011. Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B.. BMC Biology, .
20838243not listedHowell, O.W., et al. 2010. Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis.. Journal of Neuropathology & Experimental Neurology, 1017-1033.
185228481:600Windrem, M.S., et al. 2008. Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse.. Cell Stem Cell, 553-565.
Immunohistochemistry: Rat
PMID Dilution Publication
361632831:500Hari, K., et al. 2022. GABA Facilitates Spike Propagation Through Branch Points of Sensory Axons in the Spinal Cord. Nature Neuroscience, 1288-1299.
303777331:400Greguske, E.A., et al. 2019. Calyx junction dismantlement and synaptic uncoupling precede hair cell extrusion in the vestibular sensory epithelium during sub-chronic 3,3'-iminodipropionitrile ototoxicity in the mouse. Archives of Toxicology, 417-434.
303844171:500Mao, Y., et al. 2018. The Effects of a Combination of Ion Channel Inhibitors in Female Rats Following Repeated Mild Traumatic Brain Injury. International Journal of Molecular Science, 3408.
288069201:500O’Hare Doig, R.L., et al. 2017. Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma. BMC Neuroscience, 62.
281309231:100Arancibia-Cárcamo, I.L., et al. 2017. Node of Ranvier length as a potential regulator of myelinated axon conduction speed. Elife, e23329.
26888923not listedKim, K.X., et al. 2016. Maturation of NaV and KV channel topographies in the auditory nerve spike initiator before and after developmental onset of hearing function. . Journal of Neuroscience, 2111-2118.
259482591:1000Hirono, M., et al. 2015. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.. Journal of Neuroscience, 7082-7094.
252949861:500Tian, C., et al. 2014. Molecular identity of axonal sodium channels in human cortical pyramidal cells. . Frontiers in cellular neuroscience, 297.
22675541not listedManning, C.F., et al. 2012. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance.. PLoS One, .
217343021:250Lysakowski, A., et al. 2011. Molecular microdomains in a sensory terminal, the vestibular calyx ending.. Journal of Neuroscience, 10101-10114.
Western Blot: Mouse
PMID Dilution Publication
31910261not listedLee, M., et al. 2020. Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. Journal of Cell Biology, e201903033.
305048231:1000Nelson, N.D., et al. 2020. Ankyrin-G Regulates Forebrain Connectivity and Network Synchronization via Interaction with GABARAP. Molecular Psychiatry, 2800-2817.
319336261:500Alshammari, M.A., et al. 2019. Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model. Neural Plasticity, 4893103.
298570151:1000Huang, T., et al. 2019. In utero electroporation-based translating ribosome affinity purification identifies age-dependent mRNA expression in cortical pyramidal neurons. Neuroscience Research, 44-52.
25948259not listedHirono, M., et al. 2015. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.. Journal of Neuroscience, 7082-7094.
242595181:2000Dagley, L.F., et al. 2014. Quantitative proteomic profiling reveals novel region-specific markers in the adult mouse brain.. Proteomics, 241-261.
Additional Publications: Unspecified
PMID Publication
28470148Kleinecke, S., et al. 2017. Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy. Elife, 6, p.e23332.. Elife, e23332.
27474220Doppler, K., et al. 2016. Auto-antibodies to contactin-associated protein 1 (Caspr) in two patients with painful inflammatory neuropathy. Brain, 2617-2630.
25732815D''Este, E., et al. 2015. STED nanoscopy reveals the ubiquity of subcortical cytoskeleton periodicity in living neurons.. Cell Report, 1246-1251.
25707359Chen, N., et al. 2015. Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes.. Biochimica et Biophysica Acta, 827-833.
25614025Hinman, J.D., et al. 2015. Molecular disorganization of axons adjacent to human lacunar infarcts.. Brain, 736-745.
25552556Jenkins, P.M., et al. 2015. Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling.. PNAS: USA, 957-964.
25413837Miyazaki, H., et al. 2014. Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum.. Nature Communications, 5525.
25362470Trimarco, A., et al. 2014. Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination.. Nature Neuroscience, 1682-1692.
25119334Salewski, R.P., et al. 2014. Transplantation of neural stem cells clonally derived from embryonic stem cells promotes recovery after murine spinal cord injury. Stem Cells and Development, 36-50.
25031414Bull, S.J., et al. 2014. Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes.. Journal of Neuroscience, 9768-9778.
24753086Yamada, J., et al. 2014. Age-related differences in oligodendrogenesis across the dorsal-ventral axis of the mouse hippocampus.. Hippocampus, 1017-1029.
24631588Leinders, M., et al. 2014. Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain.. Pain, 1150-1160.
24599470Battefeld, A., et al. 2014. Heteromeric Kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons.. Journal of Neuroscience, 3719-3732.
24431446Yao, D., et al. 2014. Neuronal expression of GalNAc transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice.. Journal of Neuroscience, 880-891.
23842490Koehler, K.R., et al. 2013. Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture.. Nature, 217-221.
23565257Liu, R., et al. 2013. An efficient method for dorsal root ganglia neurons purification with a one-time anti-mitotic reagent treatment.. PLoS One, .
23447612Petrosyan, H.A., et al. 2013. Neutralization of inhibitory molecule NG2 improves synaptic transmission, retrograde transport, and locomotor function after spinal cord injury in adult rats.. Journal of Neuroscience, 4032-4043.
23426679Kondo, Y., et al. 2013. Spontaneous optic nerve compression in the osteopetrotic (op/op) mouse: a novel model of myelination failure.. Journal of Neuroscience, 3514-3525.
23365232Chen, C.D., et al. 2013. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.. Journal of Neuroscience, 1927-1939.
23291093Horn, K.E., et al. 2013. DCC expression by neurons regulates synaptic plasticity in the adult brain.. Cell Report, 173-185.
22886464Engelhardt, M., et al. 2013. Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons.. Brian Structure and Function, 1005-1016.
23300814Takano, M., et al. 2012. MRI characterization of paranodal junction failure and related spinal cord changes in mice.. PLoS One, .
23109147Brambrink, A.M., et al. 2012. Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain.. Annals of Neurology, 525-535.
22911763Bin, J.M., et al. 2012. Oligodendrocyte precursor cell transplantation into organotypic cerebellar shiverer slices: a model to study myelination and myelin maintenance.. PLoS One, .
22623668Gasser, A., et al. 2012. An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier.. Journal of Neuroscience, 7232-7243.
22449950Bangratz, M., et al. 2012. A mouse model of Schwartz-Jampel syndrome reveals myelinating Schwann cell dysfunction with persistent axonal depolarization in vitro and distal peripheral nerve hyperexcitability when perlecan is lacking.. The American Journal of Pathology, 2040-2055.
22348182Liazoghli, D., et al. 2012. Substrate Micropatterning as a New in Vitro Cell Culture System to Study Myelination.. ACS Chemical Neuroscience, 90-95.
22159130Reimer, M.M., et al. 2011. Rapid disruption of axon-glial integrity in response to mild cerebral hypoperfusion.. Journal of Neuroscience, 18185-18194.
21988176Sun, W., et al. 2011. Paranodal myelin damage after acute stretch in Guinea pig spinal cord.. Journal of Neurotrauma, 611-619.
21838927Roza, C., et al. 2011. Accumulation of Kv7.2 channels in putative ectopic transduction zones of mice nerve-end neuromas.. Molecular Pain, 58.
21390223Huff, T.B., et al. 2011. Real-time CARS imaging reveals a calpain-dependent pathway for paranodal myelin retraction during high-frequency stimulation.. PLoS One, .
21352229Shi, Y., et al. 2011. Acrolein induces myelin damage in mammalian spinal cord.. Journal of Neurochemistry, 554-564.
21248132Pohl, H.B., et al. 2011. Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage.. Journal of Neuroscience, 1069-1080.
21177993Hunanyan, A.S., et al. 2011. Alterations of action potentials and the localization of Nav1.6 sodium channels in spared axons after hemisection injury of the spinal cord in adult rats.. Journal of Neurophysiology, 1033-1044.
20980605Chang, K.J., et al. 2010. Oligodendrocyte myelin glycoprotein does not influence node of ranvier structure or assembly.. Journal of Neuroscience, 14476-14481.
20858739Crawford, D.K., et al. 2010. Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination.. Brain, 2999-3016.
20600647Luo, S., et al. 2010. Pulpitis increases the proportion of atypical nodes of Ranvier in human dental pulp axons without a change in Nav1.6 sodium channel expression.. Neuroscience, 1881-1887.
20534825Hunanyan, A.S., et al. 2010. Role of chondroitin sulfate proteoglycans in axonal conduction in Mammalian spinal cord.. Journal of Neuroscience, 7761-7769.
20392939Glasscock, E., et al. 2010. Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy.. Journal of Neuroscience, 5167-5175.
20102598Zoga, V., et al. 2010. KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy.. Molecular Pain, .
20053889Seidl, A.H., et al. 2010. Mechanisms for adjusting interaural time differences to achieve binaural coincidence detection.. Journal of Neuroscience, 70-80.
20007460Prolo, L.M., et al. 2009. The lysosomal sialic acid transporter sialin is required for normal CNS myelination.. Journal of Neuroscience, 15355-15265.
19805030Arnaud, E., et al. 2009. SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system.. PNAS: USA, 17528-17533.
19800949Crawford, D.K., et al. 2009. Functional recovery of callosal axons following demyelination: a critical window.. Neuroscience, 1407-1421.
19535585Dours-Zimmermann, M.T., et al. 2009. Versican V2 assembles the extracellular matrix surrounding the nodes of ranvier in the CNS.. Journal of Neuroscience, 7731-7742.
19379822Dupree, J.L., et al. 2009. Myelin, DIGs, and membrane rafts in the central nervous system. Prostaglandins & Other Lipid Mediators, 118-129.
19270340Teigler, A., et al. 2009. Defects in myelination, paranode organization and Purkinje cell innervation in the ether lipid-deficient mouse cerebellum.. Human Molecular Genetics, 1897-1908.
19156860Ogawa, Y., et al. 2009. Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins.. Journal of Neuroscience Research, 3502-3510.
18945908Jarjour, A.A., et al. 2008. Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1.. Journal of Neuroscience, 11003-11014.
18550753Martin, P.M., et al. 2008. Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments. Journal of Neuroscience, 6111-6117.
18426592Luo, S., et al. 2008. Nav1.7 expression is increased in painful human dental pulp.. Molecular Pain, 16.
18400887Lasiene, J., et al. 2008. No evidence for chronic demyelination in spared axons after spinal cord injury in a mouse.. Journal of Neuroscience, 3887-3896.
16817858Rush, A.M., et al. 2006. Differential modulation of sodium channel Na(v)1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily.. European Journal of Neuroscience, 2551-2562.
23995069Viganò, F., et al. 2013. Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain.. Nature Neuroscience, 1370-1372.

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