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Our latest article goes over some of the unique traits that set Camelid antibodies apart from those derived from traditional hosts and make them perfect for many projects.
In honor of November being National Alzheimer’s Awareness Month Dr. Gary Ciment looks at Aves Labs antibodies against Amyloid Precursor Protein whose proteolytic cleavage is implicated in Alzheimer's disease.
In 2005, Dr. Sanjoy Bhattacharya approached Aves Labs with the goal of producing a set of custom antibodies that would allow his group to study the possible role of cochlin in regulating IOP and contributing to glaucoma. Cochlin had previously been shown to be involved in various unrelated genetic disorders, including those involved in blood coagulation (from which cochlin received its name -- COagulation factor C Homology) and a particular form of late-onset deafness called DFNA9 (Robertson et al., 1997). Intriguingly, these DFNA9 patients not only presented with the progressive high frequency hearing loss, but also with glaucoma.
Custom Antibody Highlights: Pou3f4-expressing non-neuronal cells regulate auditory sensory neuron development: Effects of non-neuronal cells on axonal bundling and trophic support
To understand the roles Pou3f4-positive non-neuronal cells might play, Dr. Thomas Coate (Department of Biology, Georgetown University in Washington, D.C.) asked Aves Labs for help in designing a chicken anti-mouse Pou3f4 anti-peptide antibody that would be useful in his group's immunohistochemistry (IHC) studies.
Custom Antibody Highlights: Selective Infection of Neurons in a Mouse Model of Zika Virus (ZIKV)-Infectivity
To examine the newly emerging Zika virus and its impact on the IFN-I response, Dr. Sonja Best (Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT) contacted us several years ago to make ZIKV NS5-specific antibody.
Custom Antibody Highlights: Pannexin-1 in non-neuronal cells of sensory ganglia plays a novel role in pain perception.
Dr. Eliana Scemes (Albert Einstein College of Medicine, NY) approached Aves Labs several years ago about making a Panx1-specific antibody (there are also Pannexins -2 and -3, which she did not want the antibody to recognize) that her lab could use for immunohistochemistry and other applications.