Anti-RGS14 Antibody (N133/21)

Name: Anti-RGS14 Antibody
Brand: NeuroMab
SKU: 75-170
Price: 345.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated Trial Size

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N133/21

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

Rgs14

Molecular Weight

60 kDa

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Adult rat hippocampus immunohistochemistry.

Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N133/21 (left) or N52A/42 (right) TC supe.

Immunoblot against lysates from wild-type (+/+) and RGS14 knockout (-/-) mouse brains probed with N133/21. Data courtesy of John Hepler (Emory).

Adult rat brain membrane immunoblot.

Volume: 100 µL

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Price:

$345

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Product Details

Target

RGS14

Target Description

RGS14 is a member of the RGS family (regulator of G-protein signaling) and is highly expressed in the prefrontal cortex. Hallmark domains of RGS14 include a RGS domain, two Raf-like Ras-binding domains and a GoLoco motif. RGS14 inactivates G protein a subunits. Alterations in this protein have been implicated in Schizophrenia and Alzheimer’s disease.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N133/21

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Rgs14

Molecular Weight

60 kDa

Antigen

Fusion protein amino acids 1-544 (full-length) of rat RGS14 (also known as Regulator of G-protein signaling 14, RAP1/RAP2-interacting protein and RPIP1, accession number O08773); Mouse: 95% identity (524/547 amino acids identical); Human: 86% identity (475/547 amino acids identical); 45% identity with RGS12 and other RGS proteins; Epitope mapped to within amino acids 444-490 (between 2nd Ras-binding ; GoLoco domains, PDAKTREASSIPPCRSQGCLPRTQTKDSHLPPLSSSLSVEDASGSTG, 2014 Evans et al J Comp Neurol); Mouse: 85% identity (40/47 amino acids identical); Human: 51% identity (24/47 amino acids identical)

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2179931

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not react with RGS12

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Regulator of G-protein signaling 14 (RGS14)

UniProt Details

UniProt (Human): O43566
UniProt (Immunogen Species): O08773

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Anti-RGS14 Antibody (N133/21)

Anti-RGS14 Antibody
SKU: 75-170

Product Details

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Anti-RGS14 Antibody (N133/21)

Anti-RGS14 Antibody SKU: 75-170

Product Details

Anti-RGS14 Antibody
SKU: 75-170