Anti-RGS14 Antibody (N133/21)
Primary Antibody
Mouse, Rat
N133/21
ICC, IHC, WB
Mouse
Purified
Rgs14
60 kDa
![Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N133/21 (left) or N52A/42 (right) TC supe.](http://cdn.shopify.com/s/files/1/0202/1028/6692/products/validation-image-73-170-n133-21-wb_{width}x.jpg?v=1626900622)
Adult rat brain membrane immunoblot.
![Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N133/21 (left) or N52A/42 (right) TC supe.](http://cdn.shopify.com/s/files/1/0202/1028/6692/products/validation-image-73-170-n133-21-wb_1024x.jpg?v=1626900622)
Product Specific References for Applications and Species
- Immunocytochemistry: Human | Mouse
- Immunohistochemistry: Human | Mouse | Rat
- Western Blot: Human | Mouse
| Immunocytochemistry: Human | ||
| PMID | Dilution | Publication |
| 21158412 | not listed | Vellano, C.P., et al. 2011. Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A.. Biochemistry, 752-62. |
| Immunocytochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 21158412 | not listed | Vellano, C.P., et al. 2011. Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A.. Biochemistry, 752-62. |
| Immunohistochemistry: Human | ||
| PMID | Dilution | Publication |
| 23817783 | 1:500 | Evans, P.R., et al. 2013. Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain.. Journal of Comparative Neurology, 186-203. |
| 21158412 | not listed | Vellano, C.P., et al. 2011. Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A.. Biochemistry, 752-62. |
| Immunohistochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 36309963 | 1:500 | Diethorn, E.J., et al. 2022. Postnatal Development of Hippocampal CA2 Structure and Function During the Emergence of Social Recognition of Peers. Hippocampus, . |
| 35987207 | not listed | Whitebirch, A.C., et al. 2022. Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy. Neuron, . |
| 35180391 | not listed | Lopez-Rojas, J., et al. 2022. A direct lateral entorhinal cortex to hippocampal CA2 circuit conveys social information required for social memory. Neuron, 44575. |
| 33503421 | 1:500 | Laham, B. J., et al. 2021. Newborn mice form lasting CA2-dependent memories of their mothers. Cell Reports, 108668. |
| 33410399 | 1:500 | Squires, K. E., et al. 2021. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. Journal of Biological Chemistry, 100024. |
| 33077947 | not listed | Donegan, M.L., et al. 2020. Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model. Nature Neuroscience, 1365-75. |
| 31665627 | 1:300 | Domínguez, S., et al. 2019. Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory. Cell Reports, 1099-112.e4. |
| 31442405 | not listed | Suh, J., et al. 2019. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell, 1159-1175. |
| 31319167 | 1:1000 | Alexander, G. M., et al. 2019. Modulation of CA2 Neuronal Activity Increases Behavioral Responses to Fear Conditioning in Female Mice. Neurobiology of Learning and Memory, 107044. |
| 31121074 | 1:500 | Tulke, S., et al. 2019. Expression of brain-derived neurotrophic factor and structural plasticity in the dentate gyrus and CA2 region correlate with epileptiform activity. Epilepsia, 1234-7. |
| 30926750 | 1:500-1:1000 | Salib, M., et al. 2019. GABAergic Medial Septal Neurons with Low-Rhythmic Firing Innervating the Dentate Gyrus and Hippocampal Area CA3. Journal of Neuroscience, 4527-49. |
| 30831160 | 1:100 | Takahashi, K., et al. 2019. Prenatal treatment with methylazoxymethanol acetate as a neurodevelopmental disruption model of schizophrenia in mice. Neuropharmacology, 1-14. |
| 30718902 | 1:400 | Besnard, A., et al. 2019. Dorsolateral septum somatostatin interneurons gate mobility to calibrate context-specific behavioral fear responses. Nature Neuroscience, 436-46. |
| 30067288 | 1:250 | Helton, T. D., et al. 2019. Diversity of dendritic morphology and entorhinal cortex synaptic effectiveness in mouse CA2 pyramidal neurons. Hippocampus, 78-92. |
| 30518859 | 1:50 | Leroy, F., et al. 2018. A hippocampal CA2 to lateral septal circuit disinhibits social aggression. Nature, 213-8. |
| 30301899 | 1:500 | Meira, T., et al. 2018. A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics. Nature Communications, 4163. |
| 30293821 | 1:100 | Tirko, N. N., et al. 2018. Oxytocin Transforms Firing Mode of CA2 Hippocampal Neurons. Neuron, 593–608.e3. |
| 29571919 | 1:500 | Kragness, S., et al. 2018. Age-dependent expression pattern in the mammalian brain of a novel, small peptide encoded in the 22q11.2 deletion syndrome region. Gene Expression Patterns, 95-103. |
| 29222469 | 1:400 | Raam, T., et al. 2018. Hippocampal oxytocin receptors are necessary for discrimination of social stimuli. Nature communications, 8(1), pp.1-14.. Nature Communications, 44575. |
| 28856240 | 1:10 | Palacio, S., et al. 2017. Heterogeneity in Kv2 Channel Expression Shapes Action Potential Characteristics and Firing Patterns in CA1 versus CA2 Hippocampal Pyramidal Neurons. eNeuro, ENEURO.0267-17.2017. |
| 28823730 | 1:50 | Leroy, F., et al. 2017. Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory.. Neuron, 1089–1102.e5. |
| 26748091 | 1:300 | Piskorowski, R. A., et al. 2016. Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome. Neuron, 163-76. |
| 26482541 | 1:500 | Häussler, U., et al. 2016. Mossy fiber sprouting and pyramidal cell dispersion in the hippocampal CA2 region in a mouse model of temporal lobe epilepsy. Hippocampus, 577-88. |
| 25446721 | 1:1000 | Llorens-Martín, M., et al. 2015. Novel connection between newborn granule neurons and the hippocampal CA2 field.. Experimental Neurology, 285-92. |
| 24572357 | 1:50 | Hitti, F.L., et al. 2014. The hippocampal CA2 region is essential for social memory.. Nature, 88-92. |
| 24336151 | 1:500 | Kohara, K., et al. 2014. Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits.. Nature Neuroscience, 269-79. |
| 24005307 | 1:300 | Piskorowski, R., et al. 2014. Delta-opioid receptors mediate unique plasticity onto parvalbumin-expressing interneurons in area CA2 of the hippocampus.. Journal of Neuroscience, 14567-78. |
| 23817783 | 1:500 | Evans, P.R., et al. 2013. Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain.. Journal of Comparative Neurology, 186-203. |
| 21158412 | not listed | Vellano, C.P., et al. 2011. Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A.. Biochemistry, 752-62. |
| 20837545 | not listed | Lee, S.E., et al. 2010. RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory.. Proceedings of the National Academy of Science of the United States of America, 16994-8. |
| Immunohistochemistry: Rat | ||
| PMID | Dilution | Publication |
| 34999186 | 1:250 | Park, S.B., et al. 2022. The fasciola cinereum subregion of the hippocampus is important for the acquisition of visual contextual memory. Progress in Neurobiology, 102217. |
| 26934224 | 1:400 | Kay, K., et al. 2016. A hippocampal network for spatial coding during immobility and sleep. Nature, 185-90. |
| 26806606 | 1:1000 | Alexander, G.M., et al. 2016. Social and novel contexts modify hippocampal CA2 representations of space.. Nature Communications, 10300. |
| 26644085 | 1:100 | Althaus, A.L., et al. 2016. Axonal plasticity of age-defined dentate granule cells in a rat model of mesial temporal lobe epilepsy. Neurobiology of Disease, 187-96. |
| Western Blot: Human | ||
| PMID | Dilution | Publication |
| 23817783 | 1:1000-5000 | Evans, P.R., et al. 2013. Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain.. Journal of Comparative Neurology, 186-203. |
| 23250758 | 1:50 | Vellano, C.P., et al. 2013. Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors.. The Journal of Biological Chemistry, 3620-31. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 31319167 | 1:500 | Alexander, G. M., et al. 2019. Modulation of CA2 Neuronal Activity Increases Behavioral Responses to Fear Conditioning in Female Mice. Neurobiology of Learning and Memory, 107044. |
| 28957665 | 1:500 | Basu, R., et al. 2017. Heterophilic type II cadherins are required for high-magnitude synaptic potentiation in the hippocampus. . Neuron, 160-176. |
| 23817783 | 1:1000-5000 | Evans, P.R., et al. 2013. Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain.. Journal of Comparative Neurology, 186-203. |