Immunofluorescent staining of NTERA2 cells stained with Aves Labs anti-SOX2 antibody (green) showing strong nuclear staining of endogenous SOX2. Actin filaments are stained with phalloidin (red).
Bulk Order Anti-SOX2 Antibody
SOX2, short for SRY (Sex-Determining Region Y)-Box 2, belongs to the SOX family of proteins which play essential roles in cell differentiation, development, and organogenesis. A transcription factor, SOX2 aids in the embryonic formation of the central nervous system and neural progenitor cells. It helps to maintain the pluripotency of embryonic stem cells, allowing them to differentiate. In adult tissues, SOX2 aids in neural tissue regeneration and repair, as well as the maintenance of adult neural stem cells and their ability to develop into different specialized cell types, essential for neural plasticity. Mutations or dysregulation of SOX2 have been linked to a range of neurological diseases, including neurodevelopmental disorders like aniridia (Matsushima 2011), and optic nerve hypoplasia and septo-optic dysplasia (McCabe 2010). SOX2 has also be implicated in certain brain tumors, particularly in gliomas, where its dysregulation can contribute to uncontrolled cell proliferation (Mansouri 2016).
ICC, IHC, WB
His tagged full length protein.
Human, Mouse, Rat
Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody.
Eggs from hens hyperimmunized with target were used to prepare an IgY fraction which was then subjected to antigen-specific affinity purification
Phosphate-buffered (10 mM) isotonic (0.9%, w/v) saline (“PBS," pH 7.2) with sodium azide (0.02%, w/v) added as a preservative.
No cross-reactivity reported
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Sex Determining Region Y-Box 2, Transcription Factor SOX-2, SRY-Box Transcription Factor 2, SRY-Box 2, MCOPS3, ANOP3, SRY-Related HMG-Box Gene 2