Volume: Purified: 100 µL; Purified Trial: 20 µL; TC Supernatant: 5 mL

Concentration: Purified: 1 mg/mL; TC Supernatant: Lot Specific

Clonality: Monoclonal

Form: Purified and TC Supernatant Available (select your preferred form, size and quantity before clicking "Add to Cart")

Host Species: Mouse

Immunogen: Fusion protein amino acids 208-427 (C-terminus) of mouse Arl13b (also known as ADP-ribosylation factor-like protein 13B, ADP-ribosylation factor-like protein 2-like 1, ARL2-like protein 1 and Arl2l1, accession number Q640N2)
Rat: 85% identity (189/220 amino acids identical)
Human: 68% identity (154/224 amino acids identical)
<40% identity with Arl13a

Target Description: ADP-ribosylation factor-like protein 13B (ARL13B), also known as ADP-ribosylation factor-like protein 2-like 1. Arl13B is a small GTPase with both N-terminal and C-terminal guanine nucleotide-binding motifs. Arl13B is localized to the membrane of cilia and expressed in Neuroepithelial cells and developing radial glia of the developing cerebral cortex. Mutations in this gene are the cause of Joubert syndrome 8.

Gene ID: Arl13b Arl2l1

Antibody Registry ID (RRID): AB_11001586

Physical State: Liquid

Validation and Application Notes

Molecular Weight: 50 kDa

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.

↑ back to top

Citations

• Hua K, Ferland RJ. (2017), 'Fixation methods can differentially affect ciliary protein immunolabeling..' Cilia.. 10.1186/s13630-017-0045-9.
• Badgandi HB, Hwang SH, Shimada IS, Loriot E, Mukhopadhyay S. (2017), 'Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins..' J Cell Biol.. 10.1083/jcb.201607095.
• Di Pietro C, Marazziti D, La Sala G, Abbaszadeh Z, Golini E, Matteoni R, Tocchini-Valentini GP. (2017), 'Primary Cilia in the Murine Cerebellum and in Mutant Models of Medulloblastoma..' Cell Mol Neurobiol.. 10.1007/s10571-016-0354-3.
• Guen VJ, Gamble C, Perez DE, Bourassa S, Zappel H, Gärtner J, Lees JA, Colas P. (2016), 'STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis..' Cell Cycle.. 10.1080/15384101.2016.1147632.
• Liu Y, Snedecor ER, Choi YJ, Yang N, Zhang X, Xu Y, Han Y, Jones EC, Shroyer KR, Clark RA, Zhang L, Qin C, Chen J. (2016), 'Gorab Is Required for Dermal Condensate Cells to Respond to Hedgehog Signals during Hair Follicle Morphogenesis..' J Invest Dermatol.. 10.1016/j.jid.2015.10.067.
• Kowal TJ, Falk MM. (2015), 'Primary cilia found on HeLa and other cancer cells..' Cell Biol Int.. 10.1002/cbin.10500.
• Yang N, Li L, Eguether T, Sundberg JP, Pazour GJ, Chen J. (2015), 'Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis..' Development.. 10.1242/dev.115261.
• Bhattacharyya S, Rainey MA, Arya P, Mohapatra, Mushtaq, Dutta S, George M, Storck MD, McComb RD, Muirhead D, Todd GL, Gould K, Datta K, Gelineau-van Waes J, Band V, Band H,. (2016), 'Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development..' Sci Rep.. 10.1038/srep20727.
• Stewart K, Gaitan Y, Shafer ME, Aoudjit L, Hu D, Sharma R, Tremblay M, Ishii H, Marcotte M, Stanga D, Tang YC, Boualia SK, Nguyen AH, Takano T, Lamarche-Vane N, Vidal S, Bouchard M. (2016), 'A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects..' PLoS Genet.. 10.1371/journal.pgen.1005785.
• Yao PJ, Petralia RS, Ott C, Wang YX, Lippincott-Schwartz J, Mattson MP. (2015), 'Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation..' J Neurosci.. 10.1523/JNEUROSCI.1360-15.2015.
• Endicott SJ, Basu B, Khokha M, Brueckner M. (2015), 'The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry..' Development.. 10.1242/dev.126953.
• Joiner AM, Green WW, McIntyre JC, Allen BL, Schwob JE, Martens JR. (2015), 'Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium..' J Neurosci.. 10.1523/JNEUROSCI.1708-15.2015.
• Garcia-Gonzalo FR, Phua SC, Roberson EC, Garcia G rd, Abedin M, Schurmans S, Inoue T, Reiter JF. (2015), 'Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling..' Dev Cell.. 10.1016/j.devcel.2015.08.001.
• Laclef C, Anselme I, Besse L, Catala M, Palmyre A, Baas D, Paschaki M, Pedraza M, Métin C, Durand B, Schneider-Maunoury S. (2015), 'The role of primary cilia in corpus callosum formation is mediated by production of the Gli3 repressor..' Hum Mol Genet.. 10.1093/hmg/ddv221.
• Omori Y, Chaya T, Yoshida S, Irie S, Tsujii T, Furukawa T. (2015), 'Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control..' PLoS One.. 10.1371/journal.pone.0128422.
• Chang R, Petersen JR, Niswander LA, Liu A. (2015), 'A hypomorphic allele reveals an important role of inturned in mouse skeletal development..' Dev Dyn.. 10.1002/dvdy.24272.
• Banda E, McKinsey A, Germain N, Carter J, Anderson NC, Grabel L. (2015), 'Cell polarity and neurogenesis in embryonic stem cell-derived neural rosettes..' Stem Cells Dev.. 10.1089/scd.2014.0415.
• Chen J, Laclef C, Moncayo A, Snedecor ER, Yang N, Li L, Takemaru KI, Paus R, Schneider-Maunoury S, Clark RA. (2015), 'The ciliopathy gene Rpgrip1l is essential for hair follicle development..' J Invest Dermatol.. 10.1038/jid.2014.483.
• Menzl I, Lebeau L, Pandey R, Hassounah NB, Li FW, Nagle R, Weihs K, McDermott KM. (2014), 'Loss of primary cilia occurs early in breast cancer development..' Cilia.. 10.1186/2046-2530-3-7.
• Ruppersburg CC, Hartzell HC. (2014), 'The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis..' Mol Biol Cell.. 10.1091/mbc.E13-10-0599.
• Tuz K, Bachmann-Gagescu R, O'Day DR, Hua K, Isabella CR, Phelps IG, Stolarski AE, O'Roak BJ, Dempsey JC, Lourenco C, Alswaid A, Bönnemann CG, Medne L, Nampoothiri S, Stark Z, Leventer RJ, Topçu M, Cansu A, Jagadeesh S, Done S, Ishak GE, Glass IA, Shendure J, Neuhauss SC, Haldeman-Englert CR, Doherty D, Ferland RJ. (2014), 'Mutations in CSPP1 cause primary cilia abnormalities and Joubert syndrome with or without Jeune asphyxiating thoracic dystrophy..' Am J Hum Genet.. 10.1016/j.ajhg.2013.11.019.
• Hollingsworth TJ, Gross AK. (2013), 'The severe autosomal dominant retinitis pigmentosa rhodopsin mutant Ter349Glu mislocalizes and induces rapid rod cell death..' J Biol Chem.. 10.1074/jbc.M113.495184.
• Hassounah NB, Nagle R, Saboda K, Roe DJ, Dalkin BL, McDermott KM. (2013), 'Primary cilia are lost in preinvasive and invasive prostate cancer.' PLoS One.. 10.1371/journal.pone.0068521.
• Piotrowska-Nitsche K, Caspary T. (2012), 'Live imaging of individual cell divisions in mouse neuroepithelium shows asymmetry in cilium formation and Sonic hedgehog response..' Cilia.. 10.1186/2046-2530-1-6.
• Heydet D, Chen LX, Larter CZ, Inglis C, Silverman MA, Farrell GC, Leroux MR. (2013), 'A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice..' Dev Neurobiol.. 10.1002/dneu.22031.

↑ back to top